Mechanisms for differentiation between cognate and near-cognate ligands by purine riboswitches
نویسندگان
چکیده
منابع مشابه
Differentiating between Near- and Non-Cognate Codons in Saccharomyces cerevisiae
BACKGROUND Decoding of mRNAs is performed by aminoacyl tRNAs (aa-tRNAs). This process is highly accurate, however, at low frequencies (10(-3) - 10(-4)) the wrong aa-tRNA can be selected, leading to incorporation of aberrant amino acids. Although our understanding of what constitutes the correct or cognate aa-tRNA:mRNA interaction is well defined, a functional distinction between near-cognate or...
متن کاملEffects of cognate, non-cognate and synthetic CXCR4 and ACKR3 ligands on human lung endothelial cell barrier function
Recent evidence suggests that chemokine CXCL12, the cognate agonist of chemokine receptors CXCR4 and ACKR3, reduces thrombin-mediated impairment of endothelial barrier function. A detailed characterization of the effects of CXCL12 on thrombin-mediated human lung endothelial hyperpermeability is lacking and structure-function correlations are not available. Furthermore, effects of other CXCR4/AC...
متن کاملLarge-Scale Cognate Recovery
We present a system for the large scale induction of cognate groups. Our model explains the evolution of cognates as a sequence of mutations and innovations along a phylogeny. On the task of identifying cognates from over 21,000 words in 218 different languages from the Oceanic language family, our model achieves a cluster purity score over 91%, while maintaining pairwise recall over 62%.
متن کاملNear-Cognate Codons Contribute Complexity to Translation Regulation
The interplay between translation initiation, modification of translation initiation factors, and selection of start sites on mRNA for protein synthesis can play a regulatory role in the cellular response to stress, development, and cell fate in eukaryotic species by shaping the proteome. As shown by Ivanov et al. (mBio 8:e00844-17, 2017, https://doi.org/10.1128/mBio.00844-17), in the filamento...
متن کاملNonsense suppression by near-cognate tRNAs employs alternative base pairing at codon positions 1 and 3.
Premature termination codons (PTCs) in an mRNA ORF inactivate gene function by causing production of a truncated protein and destabilization of the mRNA. Readthrough of a PTC allows ribosomal A-site insertion of a near-cognate tRNA, leading to synthesis of a full-length protein from otherwise defective mRNA. To understand the mechanism of such nonsense suppression, we developed a yeast system t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: RNA Biology
سال: 2012
ISSN: 1547-6286,1555-8584
DOI: 10.4161/rna.20106